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Ucsc Genome

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UCSC Genome Browser REST API — reference genome assemblies for ~250 species, the annotation tracks…

v0.1.1 · active · repository · website · descriptor JSON · versions

An agent can connect right now, no human step.Remote endpoint, no authentication, reachable on the last probe.
Quality–not scored
Trust97of 100
Uptime, 30 days98%
Latency p5029 ms

Connect

8 clients · secrets stay placeholders
{
  "mcpServers": {
    "ucsc-genome": {
      "type": "http",
      "url": "https://gateway.pipeworx.io/ucsc-genome/mcp"
    }
  }
}
claude mcp add --transport http ucsc-genome https://gateway.pipeworx.io/ucsc-genome/mcp
[mcp_servers.ucsc-genome]
url = "https://gateway.pipeworx.io/ucsc-genome/mcp"
{
  "$schema": "https://opencode.ai/config.json",
  "mcp": {
    "ucsc-genome": {
      "type": "remote",
      "url": "https://gateway.pipeworx.io/ucsc-genome/mcp",
      "enabled": true
    }
  }
}
{
  "mcpServers": {
    "ucsc-genome": {
      "type": "http",
      "url": "https://gateway.pipeworx.io/ucsc-genome/mcp"
    }
  },
  "deeplink": "cursor://anysphere.cursor-deeplink/mcp/install?name=ucsc-genome&config=eyJ0eXBlIjoiaHR0cCIsInVybCI6Imh0dHBzOi8vZ2F0ZXdheS5waXBld29yeC5pby91Y3NjLWdlbm9tZS9tY3AifQ%3D%3D"
}
{
  "servers": {
    "ucsc-genome": {
      "type": "http",
      "url": "https://gateway.pipeworx.io/ucsc-genome/mcp"
    }
  }
}
{
  "mcpServers": {
    "ucsc-genome": {
      "httpUrl": "https://gateway.pipeworx.io/ucsc-genome/mcp"
    }
  }
}
extensions:
  "ucsc-genome":
    enabled: true
    name: "ucsc-genome"
    type: streamable_http
    uri: "https://gateway.pipeworx.io/ucsc-genome/mcp"
    timeout: 300

Quality – / 100not scored

Not scored: fewer than three checks apply, usually because no remote answered a credential-free probe or the server is a local package.

protocol75 · weight 25
  • warn
    protocol.modernnewest supported version is 2025-03-26; 2026-07-28 not supported, older versions are deprecated until 2027-07-28
  • n/a
    protocol.statelessonly applies to 2026-07-28 servers
  • pass
    protocol.transportstreamable HTTP
  • n/a
    protocol.list_ttlonly applies to 2026-07-28 servers
authorizationn/a · weight 15
  • n/a
    auth.prm, auth.as_metadata, auth.cimdno remote uses OAuth
  • n/a
    auth.secret_in_urlno templated URL
tool hygienen/a · weight 30
  • n/a
    tools.descriptions, tools.description_length, tools.schemas, tools.annotations, tools.directory_hints, tools.token_cost, tools.api_dumptool list unknown (behind auth, not probed, or empty)
stabilityn/a · weight 15
  • n/a
    stability.changes, stability.rug_pulltool list unknown
dependenciesn/a · weight 15
  • n/a
    deps.known_vulns, deps.mcp_sdk_version, deps.resolvableno npm or PyPI package

Tool list unknown · tools last changed 2026-10-20 · checked 2026-10-20 19:42 UTC

Tool changes

  • polymarket_edgesremoved

    Scan top Polymarket markets and return opportunities where Pipeworx data disagrees with market price. Built for "what should I bet on today" — agents discover opportunities without paging hundreds of markets. FIVE MODEL FAMILIES grouped into three response segments under by_segment: (1) MODEL_DRIVEN — crypto_price (lognormal barrier from 90d FRED log-returns) and news_momentum (GDELT 7d/21d article-volume ratio, soft signal w/ halved Kelly). (2) STRUCTURAL_ARBITRAGE — partition_overround on mutually-exclusive events; per-leg favorite-longshot bias correction with per-sport α (tennis 1.02, soccer 1.10, MMA 1.15, default 1.0); placeholder-slug filter drops will-person-X / will-team-Y / will-manager-Z / will-someone-else- backstops; partitions with >20% placeholder fraction skipped entirely. (3) CONCENTRATED_LONGSHOT — basket trade when one leg ≥75% AND ≥2 longshots ≤8% AND portfolio return ≥25:1; rare-by-design (gates relaxed Run 8 from prior 85%/5%/50:1). EVERY OPPORTUNITY carries edge_pp_net (net of slippage AND Polymarket's own taker fee — fees_pp_applied itemises the fee component; see fees.ts for the published per-category schedule), kelly_fraction + kelly_fraction_half (capped at 0.25), market.liquidity, market.spread_pp, market.volume, plus a 24h-move warning ("Market moved X.Xpp in 24h") when the recent move alone exceeds the edge — your edge may already be in the price. TRADEABLE-EDGE KNOBS: min_liquidity / max_spread_pp drop opportunities where edge isn't realizable; min_partition_leg_kelly filters partitions by best per-leg Kelly. RESPONSE TOP-LEVEL: by_segment{model_driven,structural_arbitrage,concentrated_longshot}, fed_candidates/fed_note (Fed bets surface here, excluded from ranking — 1m-T vs EFFR signal is unreliable at meeting-month horizons without paid OIS/SOFR-futures data), and _diagnostics{concentrated_longshot:{...funnel counters},category_counts,filter_skips} so callers can see WHY a segment is empty (top-N stale, all candidates failed gates, knob dropped them). Cached 1h at the KV level keyed on all knobs.

  • polymarket_arbitrageremoved

    Find arbitrage opportunities on Polymarket via monotonicity violations + partition-sum checks. Call with NO args for a `trending_scan` of the top ~200 markets by weekly volume; pass `event` for the strongest per-event partition_check, or `topic` for a themed cross-event scan. `event` (recommended for a specific market): pass a Polymarket event slug like "fed-decision-may-2026" or "when-will-bitcoin-hit-150k"; walks child markets, checks date-axis / threshold-axis ordering AND computes the partition_check (sum of YES prices across mutually-exclusive legs — should ≈1; deviations >3pp emit a BUY/SELL EVERY LEG signal). `topic` (for cross-event scanning): pass a seed question like "Strait of Hormuz traffic returns to normal" or "Fed rate decision"; searches related events across the platform, flattens markets, runs the comparator on the union. Cross-event mode catches "...by May 31" vs "...by Jun 30" patterns that single-event misses. SEMANTIC ANCHOR: cross-event pairs require ≥0.30 Jaccard similarity on question tokens (prevents Powell-Fed-Pause being paired with Powell-DOJ-probe); skipped_low_similarity surfaces the rejected pair count. PARTITION FILTER: drops will-person-X / will-manager-Y / will-someone-else- placeholder slugs; partitions with >20% placeholder fraction return null arb signal. Response: opportunities[] (gap_pp, suggested_trade, reasoning, monotonicity violation context), and in event mode partition_check{sum_yes_prices, gap_from_1, placeholders_filtered, suggested_trade}. FEES: every opportunities[] row and partition_check.arbitrage carry edge_pp_gross (== gap_pp / overround_pp), fees_pp, edge_pp_net, net_positive, plus polymarket_fee_pp, fee_basis and fee_categories[]. BOTH cost components are modeled: Polymarket's own per-category TAKER FEE (fee = shares × rate × p × (1-p), rates crypto 0.07 / sports-economics-culture-weather-other 0.05 / finance-politics-mentions-tech 0.04, geopolitics and world events fee-free; verified against Polymarket's own docs as of 2026-09-13) and Polygon gas (~$0.02/leg). The taker fee dominates: ~$1.75 per 100 shares on a crypto market at 50c versus $0.02 of gas, so rows that looked profitable before fleet #1927 may now show net_positive:false — that is the correction, not a regression. Each leg is priced at ITS OWN market's rate and price (the fee curve peaks at 50c and falls toward both extremes). fee_basis says where the rate came from: 'payload' (read off the market, the normal case), 'category' (mapped from its fee category), 'fee_free', or 'fallback' (rate unknown — charged at the modal 0.05 rather than assumed free, so an unreadable market is never reported as costless). Where fill_check reprices against live depth, this does NOT double-count that spread cost. FILL CHECK: when the partition signal fires, arbitrage.fill_check prices it against live CLOB depth (theoretical_edge_pp_at_book vs realizable_edge_pp at 1000 shares/leg, thin_legs[]) — realizable_edge_pp ≤ 0 means the overround exists only at last-trade, not in the book; do not trade it. For custom sizing use polymarket_fill_risk.

  • bet_researchremoved

    Research a Polymarket bet by pulling the relevant Pipeworx data for it in one call. Pass a market slug ("will-kristi-noem-win-the-2028-republican-presidential-nomination"), a polymarket.com URL, or a question text. Prefer an UNDATED slug: a dated one ("...-by-june-30-2026") stops resolving the day it settles, because Polymarket de-indexes resolved markets. The tool resolves the market, classifies the bet, fans out to category-specific data packs in parallel, and returns an evidence packet + simple market-vs-model comparison. Use for "should I bet on X", "what does the data say about Y", or "is there edge in Z". CLASSIFIERS: crypto_price, fed_rate, geopolitical, sports, sports_championship, drug_approval, election_candidate, tech_launch, space_launch, corporate, corporate_earnings, corporate_event, public_figure_speech, weather, other. FAN-OUT EXAMPLES: BTC bet → coingecko + fred + gdelt+gnews; Fed bet → fred (DFEDTARU + EFFR + CPIAUCSL) + kalshi_macro (KXFED implied probs) + recent_fed_actions (federal-register rules, last 365d); Hormuz bet → imf_portwatch + airspace + gdelt; Yankees WS → mlb_stats_standings + parent_event partition + news; hottest-year bet → climate_projection_nyc + gistemp_latest (NASA global anomaly, rank since 1880) + news; NVDA-vs-AAPL → finnhub get_quote + edgar shares-outstanding (derived market cap) + edgar filings + news. RESPONSE SHAPES: result.market carries best_bid/best_ask/spread_pp/liquidity/price_change_1h/1d/1w; result.analysis carries model_probability/edge_pp/kelly_fraction_half when a closed-form model fires PLUS a 24h-move warning ("Market moved X.Xpp in 24h, comparable to model edge — your edge may already be priced in") when relevant; result.evidence is keyed by source. RESOLVER CONTRACT: result.market_match_confidence ∈ {high, medium, low, none}, market_match_score (0-1 token-overlap), market_match_alternatives[] (other candidate markets the resolver considered), and suggestions[] (explicit re-query hints when the match is fuzzy) — ALWAYS inspect these before trusting the analysis block, because medium/low matches can still surface other fields. PARENT_EVENT EXTRACTOR: when the bet is one leg of a partition (Yankees WS, Romania election), result.parent_event{matched_candidate, top_legs_by_price[], partition_size, placeholders_filtered} gives you the peer prices in one place — that's the headline for elections/championships. NEWS FIELDS: news entries carry _fallback_attempted / _fallback_failed_reason / retry_after_sec when GDELT 429s and GNews backfill ran or failed. SAFETY: low-confidence resolutions short-circuit with status:"low_confidence_match" and suppress analysis fields so agents can't accidentally size on phantom matches. Closed/dead markets that ARE still indexed by Polymarket (yes_price≈0, no volume, no liquidity) return status:"market_closed_or_inactive" and skip fan-out. A market whose own deadline has already passed returns status:"market_expired_or_resolved" + expired_deadline (the date), which is deliberately NOT the same answer as low_confidence_match: your slug was right and is merely settled, so the useful retry is the successor market for the same question, not a corrected spelling. In practice resolved markets are usually de-indexed and instead surface via one of those two paths — both routes are BLOCKING, just different mechanisms. Wide-spread markets (>10pp) carry tradeability:"illiquid_wide_spread" + an explanatory note. RESOLUTION-RULE RISK: market.cancellation_rule parses the void/postponement settlement out of the resolution text — refund_50_50 (shares settle flat 50¢ on void; EV-material for any entry away from 50¢, with ev_impact quantified), resolves_no_on_cancel, resolves_yes_on_cancel, carries_to_reschedule, or mentioned_unclear. null means the description never mentions cancellation. Check this before sizing sports/esports/event-occurrence bets — audited arb-bot ledgers show flat-50¢ void settlements are a recurring pure-rules loss.

  • discover_toolsremoved

    Find tools by describing the data or task. Use when you need to browse, search, look up, or discover what tools exist for: SEC filings, financials, revenue, profit, FDA drugs, adverse events, FRED economic data, Census demographics, BLS jobs/unemployment/inflation, ATTOM real estate, ClinicalTrials, USPTO patents, weather, news, crypto, stocks. Returns the top-N most relevant tools with names, descriptions, and full input schemas (with curated examples) — each result is ready to call directly, no second schema lookup needed. Call this FIRST when you have many tools available and want to see the option set (not just one answer).

  • ask_pipeworx_groundedremoved

    Hallucination-resistant answer mode for high-stakes reads. Same routing as ask_pipeworx — picks the right tool from 7,013 across 1847 sources, fills arguments, fetches the data — then EXTRACTS the answer using ONLY what the tool result contains. Returns {answer, evidence (verbatim quote), confidence, source, fetched_at, refusal_reason:null} on success, OR an explicit refusal {answer:null, refusal_reason:"not_in_source"|"no_tool_match"|"tool_error"|"data_truncated"|"llm_error"} when the data doesn't directly answer. Use whenever an answer will be quoted, cited, or acted on, and the agent must not invent facts (financial verdicts, legal claims, medical lookups, public statements). Costs one extra LLM call vs ask_pipeworx — prefer ask_pipeworx for casual lookups.

  • ask_pipeworx_betaremoved

    Beta version of ask_pipeworx: identical universal router (same 7,013 tools, same arguments, same response shape) with candidate routing improvements enabled live whenever one is under test. No candidate is active right now (the last was retired on outcome evidence 2026-07-26), so this currently matches ask_pipeworx exactly. Use it exactly like ask_pipeworx when you want the newest routing; results are compared against the stable router to decide what merges. Falls back to nothing — this IS a full working router, just the experimental edge.

  • ucsc_sequenceremoved

    "What is the DNA sequence at [chr:start-end]" / "get the reference bases for [region] in hg38" / "pull the sequence around [variant position]" — AUTHORITATIVE reference DNA for a genomic interval from the UCSC assembly, returned as a plain base string with its GC content. Use it to check what the reference allele actually is at a position, to extract primer/probe context, or to pull a promoter or exon sequence. The assembly argument is required because the same coordinates return different bases in hg19 and hg38.

  • ucsc_tracksremoved

    "What annotation tracks does UCSC have for hg38" / "does [assembly] have a [ClinVar/GENCODE/conservation/repeat] track" / "what is the track name for [dataset] in the genome browser" — lists the annotation tracks available on one UCSC assembly, with each track's internal name, short and long label, data type and parent container. AUTHORITATIVE for the `track` argument of ucsc_track_data: the browser shows human-readable labels, the API wants the internal name (e.g. label "GENCODE V50" is track `knownGene`), and there is no way to guess one from the other.

  • archive_compareremoved

    What changed on a web page between two dates? Resolves the archived capture nearest each date (Internet Archive Wayback Machine, Common Crawl, Arquivo.pt), extracts the readable text of both, and returns a text-level diff: the segments removed and added, a similarity score, and both capture timestamps with their gaps from the requested dates. It diffs readable text, not markup, so a restyled page with the same words reads changed:false. Identical captures answer changed:false with the reason (same capture, identical content digest, or identical text), never an empty diff. A date with no capture within max_gap_days (default 30) answers status "no_capture", naming which side is missing and the nearest captures to it. Typical uses: how a privacy policy, terms of service, pricing or product page changed; whether a statement was on a page at a given time.

  • release_calendar_marketsremoved

    JOIN of the official release calendar (econ data, the FOMC, FDA decisions, SEC rules) against LIVE Polymarket/Kalshi markets — which scheduled releases land in the next N hours, and which live markets resolve on them. This is a POSITIONING tool, not a speed product: results are cached like every other pack (≤ 60s TTL) and there is no push/webhook — do not use this to try to beat a release, use it to see what is coming and what is already priced. CATEGORIES: econ (CPI, Employment Situation/jobs report, GDP, PCE, PPI, retail sales, housing starts, jobless claims — via fred_release_dates per known release_id, since FRED's own cross-release calendar mostly returns recent actuals, not future dates), fed (the next FOMC meeting's rate decision, via fomc_calendar), fda (PDUFA action dates + FDA advisory-committee meetings, via pdufa_catalysts / fda_adcom_calendar), sec (SEC final rules whose own DATES clause names an effective date in the window, via federal-register recent_rules — usually finds nothing in a short window since SEC rules typically take effect 30–60 days out, which is an accurate answer, not a bug), court (ALWAYS EMPTY today — court-listener has no forward-looking scheduled-hearing calendar, only filing/termination dates, so this category returns zero releases with unsupported:true rather than fabricate one). Omit `categories` or pass "all" for every category. MATCHING AND ITS HONESTY CONTRACT: every release is returned even when it has ZERO matched markets — a release is never dropped just because nothing on Polymarket or Kalshi resolves on it (most FDA/SEC releases will show markets:[]; that is signal, not a gap). Every matched market carries resolves_on_this_release: "true" (the venue's own close/end date sits within ~36h of the release AND the question passed a subject filter — econ and fed only), "likely" (same subject filter, but the venue closes days away from the release date), or "unclear" (a keyword hit with no date to anchor against — always true for the fda category, which has no ladder structure to check a date against). matched_by names the mechanism (a Kalshi series ticker, a Polymarket search query, or an FDA keyword probe) so a caller can judge the match rather than trust a label. scheduled_at carries both `utc` and `et`; econ releases use the standing BLS/Census 8:30am ET convention (FRED's calendar itself has no clock time), FOMC decisions use the 2:00pm ET convention, and FDA/SEC dates are date_only:true (no reliable clock time exists for either). DO NOT treat a matched market as a real arbitrage or a settled fact on its own — a market question sharing tokens with a release name is not proof it settles on that release's own published number. Call resolution_audit / resolution_diff (fleet #1909) on a specific market before sizing anything here. An empty window (zero releases across every requested category) returns the SAME shape as a populated one — release_count:0, releases:[] — plus empty_reason:"no_releases_in_window" and a `hint` telling you to widen, so you never branch on the response shape and never have to guess whether zero means "nothing is scheduled" or "the lookup failed". Econ releases especially cluster on specific dates each month, so a 48h window often straddles a dead stretch.

Showing the latest 10. Full history: list_changes · trend: quality JSON.

Checks run on what our credential-free, read-only probes observe; tools are never called and no code audit is performed. How it is computed.

Trust 97 / 100

provenance90
liveness99
freshness100
hygiene100

+repository +namespace-matches-repo +website +reachable +uptime-98% +updated-24d-ago

Derived from observable signals (official registry feed and our own credential-free probes); no code audit performed. How it is computed.

Endpoints

remoteauthreachableuptime 30dp50protocollast ok
https://gateway.pipeworx.io/ucsc-genome/mcp streamable-httpnoneyes98%29 ms2025-03-262026-10-20

Tools (0)

No tools observed. Tools appear once a credential-free probe can list them.

Schemas: list_tools.

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Official server.json
{
  "name": "io.github.pipeworx-io/ucsc-genome",
  "title": "Ucsc Genome",
  "$schema": "https://static.modelcontextprotocol.io/schemas/2025-12-11/server.schema.json",
  "remotes": [
    {
      "url": "https://gateway.pipeworx.io/ucsc-genome/mcp",
      "type": "streamable-http"
    }
  ],
  "version": "0.1.1",
  "repository": {
    "url": "https://github.com/pipeworx-io/mcp-ucsc-genome",
    "source": "github"
  },
  "websiteUrl": "https://pipeworx.io/packs/ucsc-genome",
  "description": "UCSC Genome Browser REST API — reference genome assemblies for ~250 species, the annotation tracks…"
}