Search / ai.nullary/nullary
nullary
R0· no sign-inNegative results intelligence for drug discovery — query measured failures via MCP.
v1.0.1 · active · repository · descriptor JSON · versions
Search / ai.nullary/nullary
R0· no sign-inNegative results intelligence for drug discovery — query measured failures via MCP.
v1.0.1 · active · repository · descriptor JSON · versions
{
"mcpServers": {
"nullary": {
"type": "http",
"url": "https://mcp.nullary.ai/mcp"
}
}
}claude mcp add --transport http nullary https://mcp.nullary.ai/mcp[mcp_servers.nullary]
url = "https://mcp.nullary.ai/mcp"
{
"$schema": "https://opencode.ai/config.json",
"mcp": {
"nullary": {
"type": "remote",
"url": "https://mcp.nullary.ai/mcp",
"enabled": true
}
}
}{
"mcpServers": {
"nullary": {
"type": "http",
"url": "https://mcp.nullary.ai/mcp"
}
},
"deeplink": "cursor://anysphere.cursor-deeplink/mcp/install?name=nullary&config=eyJ0eXBlIjoiaHR0cCIsInVybCI6Imh0dHBzOi8vbWNwLm51bGxhcnkuYWkvbWNwIn0%3D"
}{
"servers": {
"nullary": {
"type": "http",
"url": "https://mcp.nullary.ai/mcp"
}
}
}{
"mcpServers": {
"nullary": {
"httpUrl": "https://mcp.nullary.ai/mcp"
}
}
}extensions:
"nullary":
enabled: true
name: "nullary"
type: streamable_http
uri: "https://mcp.nullary.ai/mcp"
timeout: 300
protocol.modernnewest supported version is 2025-11-25; 2026-07-28 not supported, older versions are deprecated until 2027-07-28protocol.statelessonly applies to 2026-07-28 serversprotocol.transportstreamable HTTPprotocol.list_ttlonly applies to 2026-07-28 serversauth.prm, auth.as_metadata, auth.cimdno remote uses OAuthauth.secret_in_urlno templated URLtools.descriptionsevery tool has a descriptiontools.description_lengthdescriptions are concisetools.schemasevery tool has an object input schematools.annotations35 of 35 tools declare readOnlyHint or destructiveHinttools.directory_hintsevery tool declares readOnlyHint, destructiveHint, idempotentHint and openWorldHinttools.token_costabout 7,995 tokens to load every tooltools.api_dumptools are not a one-to-one API dumpstability.changesno tool changes in 30 daysstability.rug_pullno tool changed its meaning under the same namedeps.known_vulns, deps.mcp_sdk_version, deps.resolvableno npm or PyPI packageNo tool definition changes recorded. A server's first observation is its baseline; later probes record what changes.
Checks run on what our credential-free, read-only probes observe; tools are never called and no code audit is performed. How it is computed.
+repository +dns-namespace +reachable +uptime-100% ~updated-149d-ago
Derived from observable signals (official registry feed and our own credential-free probes); no code audit performed. How it is computed.
| remote | auth | reachable | uptime 30d | p50 | protocol | last ok |
|---|---|---|---|---|---|---|
https://mcp.nullary.ai/mcp streamable-http | none | yes | 100% | 287 ms | 2025-11-25 | 2026-10-20 |
get_compoundread-only | A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources. |
get_coverageread-only | Per-modality and per-source coverage stats (honest Phase-1 numbers). |
get_finding_provenanceread-only | Full provenance + detail for a single finding by id. |
get_model_cardread-only | Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533). |
get_target_landscaperead-only | Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533). |
list_modelsread-only | Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC. |
list_top_targetsread-only | Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other). |
search_adc_linker_failuresread-only | ADC failures attributed to linker chemistry. |
search_admet_failuresread-only | Small-molecule ADMET failures. |
search_admet_failures_all_modalitiesread-only | ADMET failures across ALL modalities. |
search_ancestry_specific_failuresread-only | Ancestry-specific CRISPR failures. |
search_bispecific_format_failuresread-only | Bispecific format/engineering failures. |
search_developability_failuresread-only | Antibody developability failures. |
search_drug_drug_interaction_failuresread-only | Drug-drug interaction failures. |
search_failed_adcsread-only | ADCs that failed at any stage. |
search_failed_bispecificsread-only | Bispecifics that failed at any stage. |
search_failed_clinical_antibodiesread-only | Discontinued/terminated clinical antibodies. |
search_failed_essentiality_screensread-only | Non-dependency / failed essentiality screens. |
search_failed_guidesread-only | Failed/ineffective CRISPR guides. |
search_failed_oligonucleotidesread-only | ASOs/siRNAs that failed engagement/developability. |
search_failed_peptide_therapeuticsread-only | Failed peptide therapeutics. |
search_failed_protacsread-only | PROTACs that failed degradation/ternary/permeability. |
search_failed_replicationsread-only | Findings that failed to replicate. |
search_failed_selectivityread-only | Small molecules that failed selectivity. |
search_failed_vaccinesread-only | Failed/terminated vaccines (by pathogen/indication). |
search_inactive_compoundsread-only | Inactive small-molecule compound-target pairs. |
search_indication_historyread-only | ALL failed approaches for an indication across every modality. |
search_mechanism_failuresread-only | Approaches that failed for a mechanism (by target). |
search_oligo_delivery_failuresread-only | Oligonucleotide delivery failures. |
search_pathogen_historyread-only | Vaccine + antimicrobial + antibody failures for a pathogen. |
search_peptide_stability_issuesread-only | Peptide stability/half-life failures. |
search_protac_e3_issuesread-only | PROTAC E3-ligase recruitment / ternary failures. |
search_safety_failuresread-only | Clinical/preclinical safety failures across modalities. |
search_target_historyread-only | ALL failed approaches against a target across every modality. |
search_vaccine_immunogenicity_failuresread-only | Failed vaccine immunogen designs. |
Schemas: list_tools.
{
"name": "ai.nullary/nullary",
"$schema": "https://static.modelcontextprotocol.io/schemas/2025-09-16/server.schema.json",
"remotes": [
{
"url": "https://mcp.nullary.ai/mcp",
"type": "streamable-http"
}
],
"version": "1.0.1",
"repository": {
"url": "https://github.com/nullary-ai/nullary",
"source": "github"
},
"description": "Negative results intelligence for drug discovery — query measured failures via MCP."
}