# Opentargets

> Open Targets MCP — disease/target/drug knowledge graph.

- name: io.github.pipeworx-io/opentargets
- version: 0.1.3
- connection class: R0 (autonomous)
- trust: 96/100
- quality: –/100 (not scored)
- owner: not claimed
- descriptor: https://api.protogrid.dev/v1/servers/io.github.pipeworx-io%2Fopentargets
- tools: https://api.protogrid.dev/v1/servers/io.github.pipeworx-io%2Fopentargets/tools

**An agent can connect right now, no human step.** Remote endpoint, no authentication, reachable on the last probe.

## Connection (mcpServers)

```json
{
  "mcpServers": {
    "opentargets": {
      "type": "http",
      "url": "https://gateway.pipeworx.io/opentargets/mcp"
    }
  }
}
```


## Trust

- hygiene: 100
- liveness: 98
- freshness: 100
- provenance: 90
- drivers: +repository +namespace-matches-repo +website +reachable +uptime-96% +updated-24d-ago
- Derived from observable signals (official registry feed and our own credential-free probes); no code audit performed.

## Quality –/100 (not scored)

Not scored: fewer than three checks apply, usually because no remote answered a credential-free probe or the server is a local package.

### protocol: 75 (weight 25)

- warn `protocol.modern`: newest supported version is 2025-03-26; 2026-07-28 not supported, older versions are deprecated until 2027-07-28
- n/a `protocol.stateless`: only applies to 2026-07-28 servers
- pass `protocol.transport`: streamable HTTP
- n/a `protocol.list_ttl`: only applies to 2026-07-28 servers

### authorization: n/a (weight 15)

- n/a `auth.prm`, `auth.as_metadata`, `auth.cimd`: no remote uses OAuth
- n/a `auth.secret_in_url`: no templated URL

### tool hygiene: n/a (weight 30)

- n/a `tools.descriptions`, `tools.description_length`, `tools.schemas`, `tools.annotations`, `tools.directory_hints`, `tools.token_cost`, `tools.api_dump`: tool list unknown (behind auth, not probed, or empty)

### stability: n/a (weight 15)

- n/a `stability.changes`, `stability.rug_pull`: tool list unknown

### dependencies: n/a (weight 15)

- n/a `deps.known_vulns`, `deps.mcp_sdk_version`, `deps.resolvable`: no npm or PyPI package

- tools: unknown
- tools last changed: 2026-10-17T07:26:15.685Z
- badge: [![protogrid quality](https://protogrid.dev/badge/io.github.pipeworx-io/opentargets.svg)](https://protogrid.dev/servers/io.github.pipeworx-io/opentargets)
- Checks run on what our credential-free, read-only probes observe; tools are never called and no code audit is performed.

### Tool changes

- 2026-10-17 `target` removed
  - "Drug target profile for [gene]" / "is [gene] a druggable target" / "[gene] target info" / "target ID [ENSG...]" — fetch a drug-target profile (Open Targets uses Ensembl gene IDs as target identifiers). Returns approved symbol, name, biotype, protein IDs, pathways, synonyms. Use for target characterization in drug discovery.
- 2026-10-17 `generate_llms_txt` removed
  - Generate a production-ready llms.txt file for any URL so AI crawlers (ChatGPT, Claude, Perplexity) can index the site cleanly. Fetches the page, extracts title/description/key links, and emits the standard llms.txt markdown format. Output is a single text blob ready to drop at site-root/llms.txt. Useful for: getting a client's site indexed by AI, drafting llms.txt for your own project, or auditing how an AI crawler would see a competitor.
- 2026-10-17 `bet_research` removed
  - Research a Polymarket bet by pulling the relevant Pipeworx data for it in one call. Pass a market slug ("will-kristi-noem-win-the-2028-republican-presidential-nomination"), a polymarket.com URL, or a question text. Prefer an UNDATED slug: a dated one ("...-by-june-30-2026") stops resolving the day it settles, because Polymarket de-indexes resolved markets. The tool resolves the market, classifies the bet, fans out to category-specific data packs in parallel, and returns an evidence packet + simple market-vs-model comparison. Use for "should I bet on X", "what does the data say about Y", or "is there edge in Z". CLASSIFIERS: crypto_price, fed_rate, geopolitical, sports, sports_championship, drug_approval, election_candidate, tech_launch, space_launch, corporate, corporate_earnings, corporate_event, public_figure_speech, weather, other. FAN-OUT EXAMPLES: BTC bet → coingecko + fred + gdelt+gnews; Fed bet → fred (DFEDTARU + EFFR + CPIAUCSL) + kalshi_macro (KXFED implied probs) + recent_fed_actions (federal-register rules, last 365d); Hormuz bet → imf_portwatch + airspace + gdelt; Yankees WS → mlb_stats_standings + parent_event partition + news; hottest-year bet → climate_projection_nyc + gistemp_latest (NASA global anomaly, rank since 1880) + news; NVDA-vs-AAPL → finnhub get_quote + edgar shares-outstanding (derived market cap) + edgar filings + news. RESPONSE SHAPES: result.market carries best_bid/best_ask/spread_pp/liquidity/price_change_1h/1d/1w; result.analysis carries model_probability/edge_pp/kelly_fraction_half when a closed-form model fires PLUS a 24h-move warning ("Market moved X.Xpp in 24h, comparable to model edge — your edge may already be priced in") when relevant; result.evidence is keyed by source. RESOLVER CONTRACT: result.market_match_confidence ∈ {high, medium, low, none}, market_match_score (0-1 token-overlap), market_match_alternatives[] (other candidate markets the resolver considered), and suggestions[] (explicit re-query hints when the match is fuzzy) — ALWAYS inspect these before trusting the analysis block, because medium/low matches can still surface other fields. PARENT_EVENT EXTRACTOR: when the bet is one leg of a partition (Yankees WS, Romania election), result.parent_event{matched_candidate, top_legs_by_price[], partition_size, placeholders_filtered} gives you the peer prices in one place — that's the headline for elections/championships. NEWS FIELDS: news entries carry _fallback_attempted / _fallback_failed_reason / retry_after_sec when GDELT 429s and GNews backfill ran or failed. SAFETY: low-confidence resolutions short-circuit with status:"low_confidence_match" and suppress analysis fields so agents can't accidentally size on phantom matches. Closed/dead markets that ARE still indexed by Polymarket (yes_price≈0, no volume, no liquidity) return status:"market_closed_or_inactive" and skip fan-out. A market whose own deadline has already passed returns status:"market_expired_or_resolved" + expired_deadline (the date), which is deliberately NOT the same answer as low_confidence_match: your slug was right and is merely settled, so the useful retry is the successor market for the same question, not a corrected spelling. In practice resolved markets are usually de-indexed and instead surface via one of those two paths — both routes are BLOCKING, just different mechanisms. Wide-spread markets (>10pp) carry tradeability:"illiquid_wide_spread" + an explanatory note. RESOLUTION-RULE RISK: market.cancellation_rule parses the void/postponement settlement out of the resolution text — refund_50_50 (shares settle flat 50¢ on void; EV-material for any entry away from 50¢, with ev_impact quantified), resolves_no_on_cancel, resolves_yes_on_cancel, carries_to_reschedule, or mentioned_unclear. null means the description never mentions cancellation. Check this before sizing sports/esports/event-occurrence bets — audited arb-bot ledgers show flat-50¢ void settlements are a recurring pure-rules loss.
- 2026-10-17 `validate_claim` removed
  - "Is it true that…" / "fact check" / "verify the claim that…" / "did X really…" / "was Y actually…" / "confirm or refute" / "true or false" — natural-language claim verification against authoritative sources. Use whenever the agent needs to check whether something a user said is factually correct. Company-financial claims (revenue, net income, cash for public US companies) verify via the structured SEC EDGAR + XBRL fast path with exact percent-delta math; ANY OTHER factual claim (macro statistics, rates, prices, drug data, records) automatically falls through to the grounded pipeline — routed to the right live source, answered with verbatim evidence, then judged. Returns a verdict (confirmed / approximately_correct / refuted / inconclusive / unsupported / could_not_verify), the grounded or structured actual value with pipeworx:// citation, and reasoning. IMPORTANT for callers: could_not_verify means the check did not happen (our LLM or source failed) and carries verification_error{stage,detail} — it is NOT evidence for or against the claim, and must not be shown as one. unsupported means we looked and cover no source for it. Replaces 4–6 sequential calls (NL parsing → entity resolution → data lookup → comparison).
- 2026-10-17 `list_subscriptions` removed
  - List the caller's active subscriptions. Returns id, type, params, created_at, last_fired_at, fire_count for each. Use this to review what you're monitoring before adding more or to find an id to cancel.
- 2026-10-17 `unsubscribe` removed
  - Cancel a subscription by id. Ownership is enforced — you can only cancel your own subscriptions. The row is deactivated (not deleted) so its historical events stay available via recent_alerts.
- 2026-10-17 `ask_pipeworx_beta` removed
  - Beta version of ask_pipeworx: identical universal router (same 6,897 tools, same arguments, same response shape) with candidate routing improvements enabled live whenever one is under test. No candidate is active right now (the last was retired on outcome evidence 2026-07-26), so this currently matches ask_pipeworx exactly. Use it exactly like ask_pipeworx when you want the newest routing; results are compared against the stable router to decide what merges. Falls back to nothing — this IS a full working router, just the experimental edge.
- 2026-10-17 `target_known_drugs` removed
  - "What drugs target [gene]" / "approved drugs against [target]" / "clinical-trial drugs for [gene]" — drugs that have been clinically tested or approved against a drug target (Ensembl gene ID). Returns drug names, mechanisms, indications, clinical trial phases. Use for competitive landscape / drug-repositioning queries.
- 2026-10-17 `disease_associations` removed
  - "Best drug targets for [disease]" / "what genes are linked to [condition]" / "druggable targets in [disease]" — top drug-target candidates for a disease (EFO ID), scored by integrated evidence. Use for target discovery in a therapeutic area.
- 2026-10-17 `target_associations` removed
  - "What diseases is [gene] involved in" / "diseases associated with [target]" / "what does [gene] cause" — top disease associations for a drug target (Ensembl gene ID), scored by integrated Open Targets evidence (genetics, expression, animal models, drugs, literature, pathways). Use to triage what diseases a candidate target might address.

Full history: https://api.protogrid.dev/v1/servers/io.github.pipeworx-io%2Fopentargets/changes

## Remotes

- https://gateway.pipeworx.io/opentargets/mcp (streamable-http, auth none, reachable true, uptime30d 0.95652175)

## Packages

_none_

## Tools (0)

_none observed_