# ivive.app

> Human hepatic clearance from in-vitro CLint, with the error band measured on known drugs.

- name: app.ivive/ivive
- version: 1.0.1
- connection class: R0 (autonomous)
- trust: 83/100 flags: no-repository
- quality: 73/100 (new)
- owner: not claimed
- descriptor: https://api.protogrid.dev/v1/servers/app.ivive%2Fivive
- tools: https://api.protogrid.dev/v1/servers/app.ivive%2Fivive/tools

**An agent can connect right now, no human step.** Remote endpoint, no authentication, reachable on the last probe.

## Connection (mcpServers)

```json
{
  "mcpServers": {
    "ivive": {
      "type": "http",
      "url": "https://api.ivive.app/mcp/"
    }
  }
}
```


## Trust

- hygiene: 80
- liveness: 100
- freshness: 100
- provenance: 55
- drivers: +dns-namespace +website +reachable +uptime-100% +updated-3d-ago -no-repository
- Derived from observable signals (official registry feed and our own credential-free probes); no code audit performed.

## Quality 73/100 (new)

### protocol: 75 (weight 25)

- warn `protocol.modern`: newest supported version is 2025-11-25; 2026-07-28 not supported, older versions are deprecated until 2027-07-28
- n/a `protocol.stateless`: only applies to 2026-07-28 servers
- pass `protocol.transport`: streamable HTTP
- n/a `protocol.list_ttl`: only applies to 2026-07-28 servers

### authorization: n/a (weight 15)

- n/a `auth.prm`, `auth.as_metadata`, `auth.cimd`: no remote uses OAuth
- n/a `auth.secret_in_url`: no templated URL

### tool hygiene: 71 (weight 30)

- pass `tools.descriptions`: every tool has a description
- pass `tools.description_length`: descriptions are concise
- pass `tools.schemas`: every tool has an object input schema
- fail `tools.annotations`: no tool declares readOnlyHint or destructiveHint, so clients cannot tell safe calls from risky ones
- fail `tools.directory_hints`: no tool declares all four of readOnlyHint, destructiveHint, idempotentHint and openWorldHint; missing: target_clint (readOnlyHint, destructiveHint, idempotentHint, openWorldHint); similar_drugs (readOnlyHint, destructiveHint, idempotentHint, openWorldHint); scale_to_human (readOnlyHint, destructiveHint, idempotentHint, openWorldHint); …
- pass `tools.token_cost`: about 2,065 tokens to load every tool
- pass `tools.api_dump`: tools are not a one-to-one API dump

### stability: n/a (weight 15)

- n/a `stability.changes`, `stability.rug_pull`: tool history recorded for 3 of the 7 days needed

### dependencies: n/a (weight 15)

- n/a `deps.known_vulns`, `deps.mcp_sdk_version`, `deps.resolvable`: no npm or PyPI package

- tools: 6, about 2,065 tokens to load them all
- tool set hash: 23a13033157ec2782932576759376343
- badge: [![protogrid quality](https://protogrid.dev/badge/app.ivive/ivive.svg)](https://protogrid.dev/servers/app.ivive/ivive)
- Checks run on what our credential-free, read-only probes observe; tools are never called and no code audit is performed.

### Tool changes

_No tool definition changes recorded._

## Remotes

- https://api.ivive.app/mcp/ (streamable-http, auth none, reachable true, uptime30d 1)

## Packages

_none_

## Tools (6)

- `calc_clhep`: Hepatic and plasma clearance from in-vitro CLint, fu,mic and fu,p (IVIVE), with the observed-CL band and applicability warnings. If fu,p or fu,mic came from predict_inputs, tell the user the result rests on predicted inputs.
- `input_sensitivity`: How far plasma CL moves as each input is varied over a range, e.g. a predicted fu,p over its 50% range.
- `predict_inputs`: Predict fu,p and fu,inc from a SMILES, with structure-only human CL and Vss as second opinions. Predictions, not measurements; check the applicability verdict.
- `scale_to_human`: Predict human plasma CL from observed animal in-vivo CL (rat, dog, monkey), every applicable method with its measured error. Observed animal CL only, never predicted.
- `similar_drugs`: Most similar reference drugs to a SMILES, with observed and IVIVE-predicted clearance: how IVIVE fared on this kind of structure.
- `target_clint`: The in-vitro CLint an assay must read for a compound to reach a target plasma clearance.